The Best Supplements For Weight Loss: A Comprehensive Review

By | March 8, 2025

The Best Supplements For Weight Loss: A Comprehensive Review – What if you could burn fat, build lean muscle, and achieve all of your goals just by eating the right foods?

However, if you continue to follow a good nutrition plan and a good training program, the right things can make a big difference in your results.

The Best Supplements For Weight Loss: A Comprehensive Review

Research shows that when included in an exercise program, whey protein can increase muscle building by 9 pounds and help reduce body fat by 3 pounds in 10 weeks compared to other forms of protein[*] .

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Or take creatine for example, which according to scientific research can increase muscle mass by 2-4 pounds during 4-12 weeks of training, and prevent muscle loss during fat loss [*].

Read on to learn more about whey protein, creatine and 8 other supplements that are proven to help you lose weight and build muscle.

Here are the top 10 supplements for weight loss and muscle gain, where they should fit into your diet and exercise regimen, and how you can use them to achieve your goals.

Whey protein is a fast acting, easily digestible protein that is high in essential amino acids, making it one of the best sources of protein in the world[*].

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In addition to being more suitable to help meet daily protein needs, scientific research has shown that whey protein also has some unique benefits for active people.

Like any protein supplement, whey protein works in part by contributing to your daily protein intake.

When you consume at least 25-30% of your daily calories from quality protein sources, your body burns fat, builds muscle and recovers faster from exercise[*].

According to a 2019 study, consuming 40 grams of whey protein during resistance training can increase muscle building, although the group receiving whey protein consumed less protein daily than the placebo group[*].

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A separate double-blind trial in which recreational bodybuilders received 0.68 grams per pound of body weight of either whey protein or another form of protein daily for 10 weeks (in addition to their daily diet) he found out that

Whey can also increase satiety more than carbohydrates or other protein sources, which can contribute to easy weight loss due to diet[*].

Whether you’re looking to gain muscle, lose fat, or both, you should start by making sure you’re getting enough protein each day.

If you are physically active, use a combination of whole food protein sources and a protein shake to consume 25-30% or more of your daily calories from protein, or at least 1 gram of protein per pound of body weight, per day .

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Whey protein right before or after exercise is very effective in supporting muscle building and exercise recovery[*][*]. Contrary to the myth of low protein intake, a shake with 40 grams or more of protein works best during exercise.

Another proven way to use whey protein for muscle building is to consume at least 20-30 grams of protein (from whey or a quality food source) every 3 hours throughout the day to achieve maximum muscle protein growth. [*] .

Finally, if you suffer from overeating, you can drink water made with protein powder 15-30 minutes before your daily meal to reduce appetite and lose weight without feeling hungry at all. no time.

And as one of the most well-studied supplements, it’s also backed by plenty of scientific evidence about its safety and efficacy.

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By increasing the recycling of energy in the muscles, creatine helps you do more repetitions in the gym, resulting in more muscle mass if you put in the required work[*][*].

In some studies, this translates into approximately 2-4 pounds of additional lean muscle mass after 4-12 weeks of training with creatine supplementation[*].

And creatine has an excellent safety profile, with no adverse effects in hundreds of studies in people from children to the elderly [*].

You can take creatine on an empty stomach, mix it into a protein shake, or take it with a meal containing carbohydrates.

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At Levels, we recommend most people take 5 grams of creatine per day, then consider adjusting the dose based on results.

If you want quick results from creatine, you can take it by taking 20-30 grams for 5-7 days, then use a smaller dose to maintain your creatine levels forever.

But compared to whey protein, casein has a different structure that slows down absorption and results in a “release time” (6-7 hours or longer for casein to absorb compared to 1.5 hours for whey [*].

The difference in digestion means casein is suitable for other purposes, such as preventing the breakdown of muscle protein between meals, or building muscle with a shake before bed.

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Research has shown that casein protein is more effective when used as a long-acting protein to increase protein synthesis (muscle building), rather than in a short-acting protein (for post-workout recovery purposes, for example) [* ].

Slow-release casein also makes it a popular protein choice before bed, but research results on this technique are mixed[*]. You can only benefit if you lift weights in the evening, where casein can help increase muscle protein synthesis by 22%[*].

Some evidence also suggests that casein is more effective than whey in reducing appetite and food intake when taken before a meal, although other studies have shown the opposite[*][*].

You can compare their effects before eating and see which one is best for you, or even mix whey and casein in equal parts to reduce your appetite.

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Also, casein seems to work better for long-term weight loss than whey protein, so it’s a better choice if you’re not going to eat for a while[*].

For most people, 40 grams of casein at a time is a good start. If you are mixing with whey protein, try mixing 20-30 grams of each type of protein into a shake or smoothie.

The scientific evidence on casein before bed is mixed, but if you want to gain as much muscle as possible, it can help.

MCT oil’s effects on increasing ketone levels and supporting fat balance make it a great supplement for people following a ketogenic diet.

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According to a 2015 meta-analysis, MCT oil was more effective in reducing body weight, waist circumference, hip circumference, total body fat, subcutaneous fat and visceral (abdominal) fat than other dietary supplements [* ].

Even if your goal isn’t fat loss, some evidence suggests that MCTs can increase fat burning if you’re eating a high-protein or low-calorie diet (for example, as part of a clean diet for weight loss)[ *].

In studies, doses of MCT oil as low as 1.7-10 grams per day have been shown to be effective for fat burning and weight loss[*].

In other words, a good starting dose of MCTs is between half a teaspoon and a teaspoon per day.

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Some people experience diarrhea when they first start taking MCT oil or when they take it on an empty stomach. If you do this, you can reduce your dose temporarily or take it with food.

Most studies do not consider the timing of MCT, but one paper states that the effect of reducing food intake is greatest one hour after a dose of MCT oil[*]. So, if you want to use MCTs for weight loss, try taking them about an hour before a meal.

One study found that women who consumed 12% of their daily calories from MCT oil (equivalent to 26-27 grams of MCT per day on a 2,000 calorie diet) experienced no adverse health effects. but instead they showed lack of fasting. blood sugar, total cholesterol and blood pressure after 16 weeks[*].

Leucine, isoleucine, and valine are branched-chain amino acids (BCAAs for short), named because of their molecular structure.

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BCAAs are a portable dietary supplement that can reduce muscle protein breakdown and promote muscle building in some cases.

BCAAs are known as essential amino acids because your body cannot make them on its own, and athletes and active people have the highest BCAA and protein requirements[*].

In other words, getting enough BCAA in your diet is very important if you are working out or want to gain muscle mass.

However, some evidence suggests people who eat a diet high in high-quality protein sources (such as whey, meat, and other animal proteins) may have enough BCAAs and will not benefit from additional supplementation[*].

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Another benefit to BCAAs is if you’re traveling or can’t get enough quality protein, which can negate the effects of not getting enough protein.

The most common dose of BCAA used in studies is 10-20 grams per day, which is effective for most people.

You can take your BCAAs on an empty stomach during exercise or in the absence of any food, but the following strategies can increase the effectiveness of BCAAs:

Selenium, zinc and magnesium are important minerals that can help support healthy hormone levels, fat loss and muscle gain.

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Even a small deficiency of this mineral can have a serious effect on hormone levels, but supplementation can correct this problem.

A 2020 randomized clinical trial found that after 3 months of following a low-calorie diet, overweight or obese participants who received 240 micrograms per day of L-selenomethionine (a supplement form of selenium) lost more fat and gained more muscular than those who did. Do not take selenium[*].

The researchers who conducted the experiment thought of oil